Study Finds Link Between Gut Mucus and Brain Disorders

A new study adds to the growing evidence that the gut and the brain are significantly connected, but this time the findings point to gut mucus.

Gut mucus is the body’s first line of defense against bad bacteria in our gut. Bacterial imbalance in the gut has been associated with Alzheimer’s disease, autism, multiple sclerosis and Parkinson’s disease, yet the exact causes are unclear.

Now a new research review of 113 neurological, gut and microbiology studies led by RMIT (Royal Melbourne Institute of Technology) University suggests a common thread — changes in gut mucus.

Senior author Associate Professor Elisa Hill-Yardin said these changes could be contributing to bacterial imbalance and exacerbating the core symptoms of neurological diseases.

“Mucus is a critical protective layer that helps balance good and bad bacteria in your gut but you need just the right amount, not too little and not too much,” Hill-Yardin said.

“Researchers have previously shown that changes to intestinal mucus affect the balance of bacteria in the gut but until now, no-one has made the connection between gut mucus and the brain.

“Our review reveals that people with autism, Parkinson’s disease, Alzheimer’s and multiple sclerosis have different types of bacteria in their gut mucus compared with healthy people, and different amounts of good and bad bacteria.”

“It’s a new gut-brain connection that opens up fresh avenues for scientists to explore, as we search for ways to better treat disorders of the brain by targeting our ‘second brain’ — the gut.”

Gut mucus is different depending on where it’s found in the gastrointestinal tract; in the small intestine it’s more porous, so nutrients from food can be easily absorbed, while in the colon, the mucus is thick and should be impenetrable to bacteria.

The mucus is full of peptides that kill bacteria, especially in the small intestine, but it can also act as an energy source, feeding some of the bacteria that live inside it.

Researchers are learning that brain disorders can affect neurons in the gut. For example, RMIT researchers have shown that neurons in both the brain and the gut nervous systems are affected in people with autism.

The new review suggests that reduced gut mucus protection may make patients with neurological diseases more likely to have gastrointestinal problems.

Gastrointestinal dysfunction in people with autism includes symptoms such as abdominal pain, diarrhea, constipation and bloating. In patients with multiple sclerosis, research has shown an increase in some types of mucosal bacteria which can favor the growth of pathogenic bacteria.

Hill-Yardin said severe gut dysfunction could worsen the symptoms of brain disorders, significantly affecting quality of life for patients and their families.

“If we can understand the role that gut mucus plays in brain disease, we can try to develop treatments that harness this precise part of the gut-brain axis,” she said.

“Our work shows that microbial engineering, and tweaking the gut mucus to boost good bacteria, have potential as therapeutic options for neurological disorders.”

Hill Yardin, an ARC Future Fellow and Vice-Chancellor’s Senior Research Fellow at RMIT, led the review with collaborators from University of Melbourne and La Trobe University.

The study is published in the journal Frontiers in Cellular and Infection Microbiology.

Source: RMIT University


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