Many Of Those Hospitalized With Advanced Cancer Struggle With Daily Tasks

A new study from Mass General Cancer Center shows that 40.2% of people who are hospitalized with advanced, incurable cancer are functionally impaired at the time of admission, meaning they require assistance with activities of daily living (ADLs) like walking, bathing, getting dressed, or other basic tasks.

Cancer patients with functional impairment also had higher rates of pain, depression, and anxiety, and were more likely to have longer hospital stays and poorer survival rates.

The findings are published in the Journal of the National Comprehensive Cancer Network (JNCCN).

“Interventions addressing patients’ functional impairment and symptom management could help enhance care delivery and outcomes for the highly symptomatic population of hospitalized patients with advanced cancer,” said lead researcher Daniel E. Lage, MD, MsC, Mass General Cancer Center.

“This highlights the need for efforts to integrate functional assessments into the care of these patients to identify individuals who may benefit from physical therapy, palliative care, and/or other supportive services earlier in their hospital stay.”

“Our finding that individuals with functional impairment experience worse survival could also help guide conversations about goals of care and hospice planning among hospitalized patients with cancer.”

Senior researcher Ryan D. Nipp, MD, MPH, Mass General Cancer Center said “We are also actively exploring interventions to help patients transition from the inpatient to the outpatient setting, which we have identified as a key challenge for patients with functional impairment.”

“Future work is needed to develop novel models of care to enhance access to palliative care services and address barriers that limit appropriate access to palliative care among patients with advanced cancer.”

For the study, the research team assessed 970 patients (ages 18 and older) with advanced cancer — defined as those not being treated with an intent to cure — who experienced an unplanned hospital admission at Mass General Cancer Center between September 2, 2014 and March 31, 2016.

The research team measured the patients’ functional impairment using nursing documentation collected at intake and stored in electronic health records (EHR). The researchers also collected self-completed questionnaires from the patients.

ADL impairment was defined as any need for assistance by another person. Overall, 390 patients (40.2%) had at least one ADL impairment with 14.8% having one or two, and 25.4% experiencing at least three areas of difficulty with daily tasks.

“Oncologists have long appreciated that functional status is a powerful predictor of a number of important outcomes including survival and treatment outcomes,” commented Toby Campbell, MD, Chief of Palliative Care at the University of Wisconsin Carbone Cancer Center, who was not involved in the new research. “We know that the routine assessment of symptom burden and functional status in the outpatient setting results in improved survival and quality of life.”

“Dr. Lage and colleagues highlight the important, often-missed, opportunity to routinely use hospitalization as a trigger for a careful assessment of symptoms and functional status. An unplanned hospitalization for an advanced cancer patient is a watershed moment and predicts higher symptoms and shorter survival in patients with and without impaired function.”

“Hospitalization is a crucial opportunity to facilitate critical serious illness care, including comprehensive palliative care and advanced care planning, with the promise of improving the lives of our patients,” said Campbell.

Source: National Comprehensive Cancer Network

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