Anxious About COVID-19? Prolonged Stress Can Impact Male Fertility, Offspring

Prolonged stress and fear driven by trying situations, such as the coronavirus pandemic, not only take a toll on mental health, but may also have a long-term impact on male sperm composition which could affect future children, according to new research conducted with mice and humans.

“There are so many reasons that reducing stress is beneficial especially now when our stress levels are chronically elevated and will remain so for the next few months,” said study corresponding author Tracy Bale, Ph.D., director of the Center for Epigenetic Research in Child Health & Brain Development at the University of Maryland School of Medicine.

“Properly managing stress can not only improve mental health and other stress-related ailments, but it can also help reduce the potential lasting impact on the reproductive system that could impact future generations.”

The study, published in the journal Nature Communications, outlines a biological mechanism for how a father’s experience with stress can influence fetal brain development in the womb.

In particular, the impact of paternal stress can be transferred to offspring through changes in the extracellular vesicles that then interact with maturing sperm. Extracellular vesicles are small membrane-bound particles that carry proteins, lipids, and nucleic acids between cells. They are produced in large amounts in the reproductive tract and play a vital role in sperm maturation.

For the study, the researchers examined extracellular vesicles from mice following treatment with the stress hormone corticosterone. After treatment, the extracellular vesicles showed dramatic changes in their overall size as well as their protein and small RNA content.

When sperm were incubated with these previously “stressed” extracellular vesicles prior to egg fertilization, the resulting offspring showed significant changes in patterns of early brain development, and as adults, these mice were also significantly different than controls for how they responded to stress themselves.

To see if similar differences occurred in human sperm, the researchers recruited students from the University of Pennsylvania to donate sperm each month for six months. The students also completed questionnaires about their perceived stress state in the preceding month.

The results show that students who had experienced elevated stress in previous months showed significant changes in the small RNA content of their sperm, while those who had no change in stress levels experienced little or no change. These data confirm a very similar pattern found in the mouse study.

“Our study shows that the baby’s brain develops differently if the father experienced a chronic period of stress before conception, but we still do not know the implications of these differences,” said Bale.

“Could this prolonged higher level of stress raise the risk for mental health issues in future offspring, or could experiencing stress and managing it well help to promote stress resilience? We don’t really know at this point, but our data highlight why further studies are necessary.”

The team did find that stress-induced changes in the male reproductive system take place at least a month after the stress has lessened and life has resumed its normal patterns. “It appears the body’s adaptation to stress is to return to a new baseline,” Bale said, “a post-stress physiological state termed allostasis.”

While the study did not test stress management interventions to determine what effects they might have on attenuating the changes in sperm composition, Bale, who goes for regular runs to reduce the stress of the current COVID-19 pandemic, believes that any lifestyle habits that are good for the brain are likely good for the reproductive system.

“It is important to realize that social distancing does not have to mean social isolation, especially with modern technologies available to many of us,” said Joshua Gordon, M.D., Ph.D., director of the National Institute of Mental Health in his web message about coping with coronavirus.

“Connecting with our friends and loved ones, whether by high-tech means or through simple phone calls, can help us maintain ties during stressful days ahead and will give us strength to weather this difficult passage.”

Source: University of Maryland School of Medicine

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